Initially, citicoline was prescribed in some European and Asian countries to improve memory, thinking, and overall mental status in patients who had previously suffered a stroke. However, with the advent of clinical studies and research on the compound, it has gradually gained recognition in nutraceutical manufacturing as an effective nootropic ingredient.
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What is Choline Sodium Powder?
Citicoline is a dietary supplement ingredient believed to support cognitive function, including focus, mood, and overall well-being. It is also said to improve vision and accelerate physical and mental performance. Essentially, citicoline occurs naturally in the body, brain cells, and tissues. Medical experts say that Citicoline plays a vital role in maintaining neurotransmitters and other enzymes in the brain. Therefore, its supplementation may help support important bodily processes.
The CAS number of sodium choline is 33818-15-4, and the molecular formula is C14H25N4NaO11P2. The molecular weight of the compound is 510.31 g/mol.
The compound ranges in purity from 98% to 99%. It is generally soluble in water and is in the form of a solid with a white appearance.
The compounds are packaged in paper drums with two layers of plastic bags when purchased in large quantities. Each drum typically contains 25kg of the compound. Prices typically range from $235 to $260 per kilogram of the compound.
Choline and Sodium Choline
Citicoline and Citicoline are closely related products and are almost often used interchangeably. However, while their roles and functions are similar, they differ in some ways.
The term citicoline is commonly used to refer to “citicoline free base,” primarily used to manufacture dietary supplements. Citicoline, on the other hand, refers to both a compound used in supplement manufacture and a prescription drug ingredient used to treat neurological disorders. These terms and the term “CDP Choline” are related and known to provide similar benefits.
Sodium Choline and CDP Choline
CDP choline and choline sodium are also closely related products, usually referring to the health supplement ingredient choline. However, their descriptions may vary, so citicoline usually refers to the exogenous or in vitro form. On the other hand, CDP Choline generally refers to the form naturally present in the body or endogenous.
Essentially, the role of CDP choline in maintaining cognitive function in the human brain is the expected effect of taking sodium choline supplements.
Sodium Choline Bulk Powder Production Process
The production of Citicoline Sodium Salt (known as Citicoline Sodium) involves a complex process developed over the years by various experts in the field. One of the commonly used methods is to use a dicarboxylic acid or a salt thereof. The method yields a 99% or better purity, as determined under high-performance liquid chromatography (HPLC) techniques.
What is the Role of Choline?
Several known pathways exist for how citicoline improves brain function and acts as a nootropic. Once in the body, citicoline is hydrolyzed into two compounds — cytidine and choline. These compounds then cross the blood-brain barrier before reforming into their original structure, citicoline. Then its anticipatory action starts in the brain.
Primarily, citicoline or CDP-choline, is a precursor for the production of acetylcholine, an essential neurotransmitter that is responsible for maintaining memory work. Also, citicoline affects levels of norepinephrine and dopamine in the central nervous system of the brain.
Another known mode of action of this compound is to promote the synthesis of membrane phospholipids. This anticipatory effect is important because it facilitates communication between nerve cells, including the efficient transmission of nerve cell impulses. Nearly all bodily functions and responses require positive nerve cell transmission.
What Does Sodium Choline Do?
As stated in the customer statement in the product review, taking pure citicoline sodium dietary supplement provides several health benefits. International scientific studies have also confirmed these claims over the years. Some of the known features of using Citicoline are as follows:
A person’s mood is affected by imbalances in neurotransmitter production in the brain. The neurotransmitters primarily responsible for mood and affect are dopamine, norepinephrine, and serotonin. After crossing the blood-brain barrier, experts say that Citicoline Sodium helps improve dopamine and norepinephrine levels, improving mood and promoting a positive outlook.
As a prescription drug, Citicoline Sodium has been evaluated as beneficial in addressing memory loss brought about by stroke and other related disorders. Within recommended doses, pure Citicoline Sodium in dietary supplements is also believed to support memory work among adults. The compound, however, is not intended to diagnose, treat, cure, or prevent other illnesses related to memory loss, such as those secondary to traumatic psychiatric conditions.
The action of the ingredient in enhancing memory is brought about by its mechanism to increase the production of the neurotransmitter acetylcholine. Hence, some experts say that the ingredient may be helpful among elderly individuals diagnosed with Alzheimer’s disease and Dementia, which often causes memory lapses.
Aside from improving positive mood and enhancing memory, Citicoline Sodium supplementation is also believed to address other mental functions, such as effective nerve signal impulse transmission and focus. Some experts also say that it may address some symptoms of substance abuse.
Citicoline Sodium Dosage
The dosage for safe supplementation usually ranges from 1000-2000 mg of citicoline per day if intended for improving cognitive functions. However, for persons intending to use the compound for eye disorders such as glaucoma, the recommended dose is 500-1600 mg of citicoline per day.
While the above-recommended dosage has been studied in scientific research, it is important to understand that it may vary depending on the person’s age, weight, and health condition. In effect, if prescription Citicoline Sodium is being used, the dosing prescribed by a physician must be followed.
Where to Buy Citicoline Sodium in Bulk?
The price for Citicoline Sodium usually ranges from $235 to $260 per kilogram. The prices may differ depending on your purchase quantity and the shipping fees in your location.
Nutriavenue offers bulk citicoline. Our store is the best source for high-quality supplement ingredients at affordable prices. Nutriavenue has been registered as an ingredient supplier with the Food and Drug Association and has passed certifications such as Kosher, GMP, and Halal.
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Top 5 Best Choline Supplements in 2024
By Prima Editorial | March 6, 2024
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Choline is an important nutrient in the human body, which is crucial for the brain function, the liver health, and the muscle movement. It is a pre-cursor of acetylcholine, a neurotransmitter implicated in memory, attention, and mood control. Despite the fact that choline can be found in many foods, such as eggs, meat, and fish, many people in the United States do not take enough of it in their diets.
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Choline supplementation can also be a convenient way of ensuring that you consume the daily requirements. But not all choline supplements are the same. The best choline supplements contain a choline form that is easily bioavailable to the body and are free from harmful additives and contaminants.
The form of choline used should be taken into account when choosing a choline supplement. There are some usual forms of choline such as choline bitartrate, alpha-GPC, and citicoline. Each type has its own advantages and disadvantages so it is important to select the one that best meets your needs.
We researched and tested many choline supplements for many hours to find the best options in the market. In the succeeding part, we shall provide our favorite choline supplements, giving a comprehensive pros and cons analysis of each.
Top 3 Best Choline Supplements
After having conducted the research and reviewed the most popular choline supplements, we managed to compile a list of the best ones for you. Choline is a nutrient that is necessary for proper brain function, liver health, and muscle movement. However, most people do not consume enough choline, so supplementation becomes a wise option. Our collection consists of items that are top-caliber, efficient, and safe. Whatever your need for a cognitive kick or long-term health improvement may be, we have suggested the top-rated choline supplements.
If you want to obtain a choline supplement for supporting your baby’s cognitive function during pregnancy and breastfeeding, then you can opt for Ritual Natal Choline Supplements.
Pros
- Supports healthy nerve transmission
- Assists in fatty acid metabolism
- Non-GMO and Kosher certified
Cons
- May cause stomach upset in some individuals
- Some users may find the capsules difficult to swallow
- May take several weeks to notice effects
We have established that the NOW Supplements Choline & Inositol 500mg brand by NOW is a reliable and a good option to those looking to take care their nerves. NonGMO and Kosher seals grant the needed advantage for those buyers who rank these things foremost in the supplements of their choice.
Although, on the one hand, it may cause an upset stomach in certain individuals, on the other hand, it should be taken together with food. Moreover, the capsules too may be big to some users, and they will therefore, not be able to consume them.
In conclusion, we believe NOW Supplements, Choline & Inositol 500 mg, will suit people who seek high-quality choline supplements and who care about the nerves performance and fatty acids absorption. However, you should be aware that it may take a month to get the initial feedback, and taking with the food will help you to reduce the stomach upset.
If a top-notch choline supplement is what you are looking for, Nested Naturals Choline Bitartrate 500mg is a great alternative that is worth serious consideration.
Pros
- Boosts cognitive performance
- Supports liver function
- Ideal for expectant mothers
Cons
- May cause a fishy odor
- May cause stomach upset in some individuals
- Requires taking two capsules for recommended dosage
We have used Nested Naturals Choline Bitartrate 500mg for several months now and reported good effects. We noticed that we got better results not only in general cognitive processes but also quick thinking which helps us to concentrate and stay alert during the day. Not only that, it was a rockstar for helping our liver and total general health.
Choline supplement is one of those stand-out features that is by its nature versatile. An inclusion of this device will be a perfect choice for those who are just learning they are pregnant, because, it communicates the status of critical health that may influence the fetus from the locus of control. Moreover, it completes the whole process of your health in terms of energy level and protection for the brain and liver as well.
However, we didn’t face any similar issues ourselves; but, some people might feel a fishy odor or an upset stomach as the side effects. Moreover, it is worth mentioning that the recommended daily dose requires taking two capsules, sometimes leading to discomfort as it is compelled to take additional medicine.
In general, we give a 100% guarantee to Nested Naturals Choline Bitartrate 500mg for those, who want to upgrade their cognitive facilitate and strengthen their liver health.
If you are looking for an organic vegetable and sprout-based whole-food choline supplement that is fermented for better absorption to support healthy brain and liver function, then PURE SYNERGY Choline Complex might be the right choice for you.
Pros
- Made with organic ingredients and fermented for better absorption
- Supports healthy brain and liver function
- Non-GMO, gluten-free, vegan, and dairy-free
Cons
- Tablets have a strong smell and can be difficult to swallow for some
- Tablets may clump together in the bottle
- Relatively new product on the market with fewer reviews compared to other choline supplements
PURE SYNERGY Choline Complex has given us a few weeks to intake, and we’ve achieved better concentration and understanding. It makes us sure that we are not just following a trend but making a choice that is cleaner morally since it is made with organic ingredients and further fermented to assist with better absorption. Another thing we enjoy about this brand is it also hits the product line of liver health which is an essential factor in general well-being.
The odor was quite strong on the tablets we tried, a surprising for some people. On the one hand, tablets themselves can be challenging to swallow for some people sometimes; and the size of tablet is also large compared to the others. Furthermore, we happened to find that some tablets clumped together, making it harder for us to pick up only one tablet.
Basically, if you are searching for a choline supplement that uses organic ingredients and keeps the brain healthy along with liver function then you can go for trying about SYNCHRONY CHOLINE COMPLEX. Mindful of the strong smell, and the chance that it takes you a longer time to swallow the pills.
If you’re seeking a choline supplement that is supportive of babies’ cognitive function during pregnancy and breastfeeding, then Ritual Natal Choline Supplements may be your go-to choice.
Pros
- Contains clinically-backed form of choline to support baby’s cognitive function from infancy to early childhood when taken during pregnancy.
- Clean Label Project Certified, Non-GMO Project Verified, and third-party tested for heavy metals, major allergens, and microbes.
- Vegan, sugar-free, gluten-free, dairy-free, nut-free, soy-free, and formulated without stevia, sugar alcohols, and artificial colors, flavors, or sweeteners.
Cons
- Only contains 550 mg of high potency choline as choline chloride, which might not be enough for some people.
- Some users reported that the pills are difficult to swallow.
- Relatively expensive compared to other choline supplements.
Natal Ritual Choline Supplements are high-quality and real-pure products that we have enjoyed using for a few weeks now. The thing that pleases us most about making this purchase is that the product comes with the CLP Certification and is assessed by non-GMO and heavy metals, main allergens, and microbes tests.
The drug in the pill is doable as the pills are normally small and can be swallowed, but some users might find their form challenging because of their shape or size. We are happy that the supplement is vegan, sugar-free, gluten-free, dairy-free, nut-free, and soy-free, and also stevia and sugar alcohols free without artificial colors, flavors, or sweeteners, enabling it to be well received by people with food restrictions or sensitivities.
However, the supplement only incorporates 550 mg of high-potency choline as choline chloride so some might not get the highest performance. The dose required may be higher for you and, in that situation, taking more pills per day or considering switching to a different supplement might be your option.
To sum up, Ritual Prenatal Choline Supplements is the best choice for moms who are seeking a pure and high-quality choline supplement, which may affect a kid’s cognitive function during pregnancy and breastfeeding. But if persons can not take in sufficient choline and they have an issue with swelling pills, then this might not be the most suitable treatment for them.
We highly recommend Nature Made Choline Supplement as it is vegan and also a gluten-free source of Cholines. A Choline of 300mg per 2 gummy serving is included, which initiates acetylcholine production to ensure better memory now, mood, and muscle health.
Pros
- The gummies are vegan and gluten-free, making them a great option for those with dietary restrictions.
- The Green Apple flavor is delicious and makes taking supplements enjoyable.
- Nature Made is the #1 Pharmacist Trusted vitamin and supplement brand, ensuring quality and safety.
Cons
- Some customers have reported that the taste is too sour or unpleasant.
- The gummies may stick together in the bottle, making it difficult to separate them.
- The price point is slightly higher than other Choline supplements on the market.
We experienced positive effects on memory and intellectual abilities while taking Nature Made Choline Supplements every day. The tablets are rather small and can be easily swallowed and digested, posing no hindrance in our daily routine. Besides, these supplements indeed are made from all-natural ingredients and they have natural taste and colors, however, they do not comprise sugar substitutes and high fructose corn syrup.
If you are vegan or on the gluten-free dietary and need an additional Choline for your brain proper function, liver function, and nervous system, please test our Nature Made Choline Supplement products.
Buying Guide
Types of Choline
For our convenience, many choline products are being sold in the market nowadays. It is known that choline bitartrate is the most common one; followed by CDP-choline and alpha-GPC. Their distinction, I would like to really highlight is great for getting new knowledge and possessing something that ideally suits you. The supplement choline bitartrate is a less expensive alternative and is normally looked upon as an option to go for, while most users of CDP-choline report benefits to the brain.
Dosage
The daily dosage of choline is different for each product but picking one that may meet your needs by the day is crucial. The appropriate choline dose for adults is widely established to be in the range of 425-550 mg, but this figure may change per variables such as sex and age of the subjects as well as the presence of certain medical conditions. Make sure that you read the label of any choline supplement well selected so as to ensure that it is as well delivering the right dosage.
Quality
It is essential to be selective to a good quality choline product that is manufactured by a reputable company when choosing the supplement for choline. Seek out supplements that have been subjected to purity and potency verification tests, and that carry good reviews from other users. Lastly, evaluating goods that are recognized by a distinct body like NSF International or the United States Pharmacopoeia is another factor that should be considered.
Price
Choline supplements come at different prices, and consequently, it is critical to pick the one that you are able to pay. Nevertheless, be aware you that the cheapest is not always the best variant. Seek supplements that are within your budget and that give the best for the money spent, and they should not compromise the quality by being affordable.
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